91΄σΟγ½Ά

91΄σΟγ½Ά
91΄σΟγ½Ά 91΄σΟγ½Ά
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Endocrinology and Molecular Medicine
Ze Zheng, MBBS, PhD

Ze Zheng, MBBS, PhD

Assistant Professor

Locations

  • Health Research Center
    Versiti Blood Research Institute

Contact Information

Education

MBBS, Clinical Medicine, Jiamusi University
PhD, The Center for Molecular Medicine and Genetics, Wayne State University
Postdoctoral Fellowship, Division of Molecular Medicine, Columbia University Medical Center
Learn more about the Ze Zheng Laboratory

Biography

Dr. Ze Zheng is an Assistant Professor of Medicine at the 91΄σΟγ½Ά, and an Associate Investigator at the Versiti Blood Research Institute, where her research laboratory is located. She received her MBBS in clinical medicine from Jiamusi University, and her PhD in molecular biology and genetics of liver metabolism from Wayne State University (mentor Kezhong Zhang, PhD). She completed her postdoctoral fellowship in cardiometabolism research at Columbia University Medical Center (mentor Ira Tabas, MD, PhD). She has published in leading journals on a broad range of topics, including fibrinolysis, thrombosis, lipid and glucose metabolism, atherosclerosis, circadian rhythm, nonalcoholic steatohepatitis (NASH), and air pollution-associated liver injuries.

Her recent studies focus on the role of hepatocyte-derived fibrinolytic enzymes in obesity-associated atherosclerosis, thrombosis and hemostasis. Her research has been funded by a Berrie Scholar Award from Russell Berrie Foundation, an NIH T32 training grant, an ASH Scholar Award from American Society of Hematology, a Career Development Award from American Heart Association, a Career Development Award from National Hemophilia Foundation, a Cullen Scholar Award from Steve Cullen Run Foundation through 91΄σΟγ½ΆCardiovascular Center, a Joan Gill Pilot Award from the Versiti Blood Center of Wisconsin, Startup Fund from 91΄σΟγ½Άand Versiti, and a recently awarded R01 from NHLBI. She serves as a member of the American Society of Hematology Task Force for PhD Careers, and the International Society of Thrombosis and Haemostasis (ISTH) Ethics Committee and the Co-Chair of ISTH Fibrinolysis Subcommittee.

Secondary Appointments

  • Associate Investigator, Versiti Blood Research Institute, Blood Center of Wisconsin
  • Member, Cardiovascular Center, 91΄σΟγ½Ά
  • Assistant Professor, Department of Physiology, 91΄σΟγ½Ά

Leadership Positions

External

  • Member, Task Force for PhD Careers, American Society of Hematology
  • Co-chair, Fibrinolysis Subcommittee, International Society on Thrombosis and Haemostasias (ISTH)
  • Member, Ethics Committee, International Society on Thrombosis and Haemostasias (ISTH)
  • Member, Conflict of Interest Policy and Process Focus Group, International Society on Thrombosis and Haemostasis (ISTH)
  • Board Member, Fredrickson Lipid Research Conference Board of Directors
  • Co-chair, Planning Committee for 2024 Fredrickson Lipid Research Conference to be held in Milwaukee, WI
  • Member, Planning Committee Member, American Heart Association Committee for Scientific Sessions Programming, representing the Council on Arteriosclerosis, Thrombosis and Vascular Biology (ATVB)

Internal

  • Member, Interdisciplinary Doctoral Program in Biomedical Sciences (IDP) Recruiting Committee, 91΄σΟγ½Ά
  • Member, Seminar Series Committee, Versiti Blood Research Institute

Research Experience

  • Atherosclerosis
  • Circadian Rhythm
  • Fatty Liver
  • Fibrinolysis
  • Lipoproteins
  • Liver Cirrhosis
  • Metabolic Syndrome
  • Obesity
  • Thrombosis

Research Interests

  • A new link between fibrinolytic proteins and dyslipidemia
  • Fibrinolysis in hemophilia
  • Fibrinolysis in COVID-19
  • Circadian regulation of basal fibrinolysis and the morning onset of thrombotic events
  • The role of hepatocyte tPA in liver injuries

Publications

  • (Zhang J, Chang J, Chen V, Beg MA, Huang W, Vick L, Wang Y, Zhang H, Yttre E, Gupta A, Castleberry M, Zhang Z, Dai W, Song S, Zhu J, Yang M, Brown AK, Xu Z, Ma YQ, Smith BC, Zielonka J, Traylor JG, Dhaou CB, Orr AW, Cui W, Zheng Z, Chen Y.) bioRxiv. 2024 Jul 15 PMID: 39071358 PMCID: PMC11275753 07/29/2024

  • (Rodriguez M, Zheng Z.) Res Pract Thromb Haemost. 2024 Mar;8(3):102394 PMID: 38706781 PMCID: PMC11066549 05/06/2024

  • (Zhang Z, Rodriguez M, Zheng Z.) Arterioscler Thromb Vasc Biol. 2024 Mar;44(3):533-544 PMID: 38235555 PMCID: PMC10922732 SCOPUS ID: 2-s2.0-85185252234 01/18/2024

  • (Sim MMS, Mollica MY, Alfar HR, Hollifield M, Chung DW, Fu X, Gandhapudi S, Coenen DM, Prakhya KS, Mahmood DFD, Banerjee M, Peng C, Li X, Thornton AC, Porterfield JZ, Sturgill JL, Sievert GA, Barton-Baxter M, Zheng Z, Campbell KS, Woodward JG, López JA, Whiteheart SW, Garvy BA, Wood JP.) bioRxiv. 2024 Feb 09 PMID: 38370737 PMCID: PMC10871343 02/19/2024

  • (Chen V, Zhang J, Chang J, Beg MA, Vick L, Wang D, Gupta A, Wang Y, Zhang Z, Dai W, Kim M, Song S, Pereira D, Zheng Z, Sodhi K, Shapiro JI, Silverstein RL, Malarkannan S, Chen Y.) Front Cardiovasc Med. 2024;11:1436865 PMID: 39156133 PMCID: PMC11327822 SCOPUS ID: 2-s2.0-85201434395 08/19/2024

  • (Dai W, Castleberry M, Zheng Z.) J Thromb Haemost. 2023 Oct;21(10):2679-2696 PMID: 37579878 PMCID: PMC10599797 SCOPUS ID: 2-s2.0-85171457835 08/15/2023

  • (Dai W, Zhang H, Lund H, Zhang Z, Castleberry M, Rodriguez M, Kuriakose G, Gupta S, Lewandowska M, Powers HR, Valmiki S, Zhu J, Shapiro AD, Hussain MM, López JA, Sorci-Thomas MG, Silverstein RL, Ginsberg HN, Sahoo D, Tabas I, Zheng Z.) Science. 2023 Sep;381(6661):eadh5207 PMID: 37651538 PMCID: PMC10697821 SCOPUS ID: 2-s2.0-85169348601 08/31/2023

  • (Zhang Z, Dai W, Zhu W, Rodriguez M, Lund H, Xia Y, Chen Y, Rau M, Schneider EA, Graham MB, Jobe S, Wang D, Cui W, Wen R, Whiteheart SW, Wood JP, Silverstein R, Berger JS, Kreuziger LB, Barrett TJ, Zheng Z.) Res Pract Thromb Haemost. 2023 Aug;7(6):102164 PMID: 37680312 PMCID: PMC10480648 09/08/2023

  • (Kahn SR, Arnold DM, Casari C, Desch KC, Devreese KMJ, Favaloro EJ, Gaertner F, Gouw SC, Gresele P, Griffioen AW, Heger L, Kini RM, Kohli S, Leader A, Lisman T, Lordkipanidzé M, Mullins E, Okoye HC, Rosovsky RP, Salles-Crawley II, Selby R, Sholzberg M, Stegner D, Violi F, Weyand AC, Williams S, Zheng Z.) Res Pract Thromb Haemost. 2023 May;7(4):100193 PMID: 37538494 PMCID: PMC10394567 08/04/2023

  • (Zheng Z, Mukhametova L, Boffa MB, Moore EE, Wolberg AS, Urano T, Kim PY.) J Thromb Haemost. 2023 Apr;21(4):1043-1054 PMID: 36759279 PMCID: PMC10109242 SCOPUS ID: 2-s2.0-85150846431 02/10/2023

  • (Puzyrenko A, Jacobs ER, Padilla N, Devine A, Aljadah M, Gantner BN, Pan AY, Lai S, Dai Q, Rubenstein JC, North PE, Simpson PM, Willoughby RE, O'Meara CC, Flinn MA, Lough JW, Ibrahim EH, Zheng Z, Sun Y, Felix J, Hunt BC, Ross G, Rui H, Benjamin IJ.) J Am Heart Assoc. 2023 Feb 21;12(4):e027990 PMID: 36789856 PMCID: PMC10111490 SCOPUS ID: 2-s2.0-85148479620 02/16/2023

  • (Yin L, Zhou T, Zheng Z, Long X, Qiu H, Lu HS.) Front Cardiovasc Med. 2023;10:1183427 PMID: 37234374 PMCID: PMC10207329 05/26/2023

Publications of from the